High proportion of new energy generation is the main feature of new power system, mining the reactive power and voltage potential of flexible resources such as new energy generation, energy storage system and flexible load can effectively improve the safe and stable operation of the novel power system. This paper presents a method of reactive power and voltage control for distribution network, which considers generation network load storage interaction. From the load demand side response, a load translation strategy for price-driven demand response is implemented based on the real-time market price information and the cost of load transfer and user purchase. The optimization model of reactive power considering the generation network load storage interaction is constructed by using the energy storage system to coordinate the output of new energy generation and load translation rules. By adjusting reactive power compensation equipment and energy storage charging and discharging strategy to coordinate the output of the new energy system, the optimal control of reactive power and voltage of the system can be achieved on the basis of meeting the response demand of load demand side. Through the simulation analysis of the improved IEEE 33-bus distribution network, the experimental results show that the full interaction of generation network load storage can effectively improve the reactive power and voltage regulation ability of the system and realize the safe and economic operation of distribution network.