Hexi Corridor region is characterized by the Gobi desert with high resistively soil.It imposes many difficulties on grounding-net processing and measurement in substations of the area. It brings many difficulties such as obtaining enough measuring electric current injection, and capacity shortage of the equipment. Due to the various disturbances, it’s frequently difficult to measure the reliable results. This paper discussed the grounding resistance measurement for a transformer substation as example in Hexi Corridor region. By selection and analysis of appropriate measurement model, It provides a fundamental data for safety operation of the equipment so as to provide a reference for similar grounding resistance measurement.