When the mobile base station and substation are built together, the electrical safety protection distance must be taken into account. In the paper, it’s analyzed that the disturbance voltage of the two cables in substation when the base station suffers the light strike, the substation switching operation and short circuit faults influencing on the base station grounding. According to the relevant national and international standards, the electrical parameters are calculated when the substation and mobile base station grounding grid connected in different ways and different distance to get the electrical safety protection distance. The conclusion provides a theoretical basis for engineering construction with the high practical value. Meanwhile, it is of great significance to develop the win-win co-operation of the power and telecommunications operators, to explore the diversified businesses of electric power.