The aim of this paper is to increase the power factor and reduce the loss of power grid. After studying the multiple-user and non-uniform power line intimately, we get its features like having a large number of users but small in the capacity and load density, and the radius of transmission line different from each other. On the basis of that study, we propose an optimized technology to improve the voltage eligibility rate and reduce active power lose of multiple-user and non-uniform power line. The technology is about to use low-voltage reactive power dynamic compensation technology with zero transition in the low-pressure side of the transformer, whose rated capacity is larger than a specific one, and use the timing services of BeiDou Navigation Satellite System to coordinate the control process. In the high pressure side, take use of sensitivity analysis techniques and follow the principles of zonal compensation to compensate in the high sensitivity with the static compensation technology. The forward-backward sweep method is adopted in the power flow calculation and the analysis of the improvement of the proposed technology. The example shows that the proposed control technique can effectively improve the quality of the voltage along the multiple-user and non-uniform power line and reduce its total active power losse.