For multiple complex area of small-bore pipeline, low velocity of flow monitoring reality needs, combined with the design thought of the low energy consumption and high precision in this paper, a combining wireless sensor network and the method of time difference ultrasonic flow measurement methods, and introduces the software and hardware design in detail. CC2530 as the control core is used in designing of ZigBee wireless sensor network, terminal equipment control TDC-GP2 chip to realize high precision transmission time difference measured, the coordinator device receives each terminal measurement data, and through a serial port to industrial platform for processing, display and storage. The test results show that the system can realize multi-channel long time continuous steady flow monitoring, and high measurement precision,it has the generalized value.