Cyclic Redundancy check (CRC) has the strong ability of error detection, overhead is small, easy to use the encoder and the realization of detection circuit, is much better than the parity and arithmetic and calibration method, the characteristics of the CRC check is added in the serial communication can ensure the effectiveness of communication. And the FPGA with flexible and stable, rapid and efficient characteristics, so the design with VHDL realization of CRC look-up table method and the optimization analysis, make its have good stability in serial communication, improve the accuracy of the data transmission.