At present, the laser self-calibration is an important way of self calibration in substation, but it is difficult to be widely used because of its high cost and short service life. Aiming at this kind of problem, this paper proposes a self calibration technique based on virtual DSP in substation. It begins by virtual real time receiving substation voltage regulation module receives the command and virtual DSP data prepared by the use of acceleration and deceleration processor to improve substation current stability, using the timing interpolation procedure to enhance the substation voltage and timing accuracy. Through the dynamic coordinates of the interpolation and the mapping of the digital signal after the refresh, the self calibration of the transformer substation is completed, the laser self calibration cost is reduced, and the voltage stability of the substation is improved. The simulation results show that the proposed method has low running cost and good practical effect.