The uncertainty of intermittent energy power generation brings great challenges to the operation and dispatch of distribution network. Active distribution network is an effective technology to realize the intermittent new energy integration in the future distribution network. Based on global and regional coordination control, proposed the long time scales of global optimization and the short time scale regional autonomy under the coordination of combining optimization method, combine the chaos optimization algorithm and the differential algorithm for solving global optimization problems, regional coordination control to the entire network optimization as a template, according to the real-time changes in regional resource and load and the processing of renewable energy, make the whole network and running in the optimal state region, and through the simulation verify the validity of the optimization scheme of research work done for the subsequent management of distributed power grid in China to provide the reference and reference.