Aiming at the increasing requirements of real-time acquisition and processing of atmospheric data parameters during the flight of modern aircraft, a design method of serial communication interface for atmospheric data solving card based on DSP and 4-channel UART chip TL16C554A is proposed . The solution card uses the high-performance floating-point DSP TMS320C6713 as the core processor, Firstly,the realization principle of the communication interface hardware circuit and the configuration method of the serial communication parameters are introduced. Secondly, the asynchronous serial communication implementation process of external extended serial port chip TL16C554A is elaborated. The CRC cyclic redundancy check improves the accuracy and reliability of data transmission.Finally, the interface communication function is tested by the test platform. The test results show that the serial communication interface can transmit data in real time, and the data refresh is fast and error-free,which can satisty the purpose of stable and reliable transmission of a large amount of data. This serial communication interface has been successfully applied to a FADS system(embedded atmospheric sensing system) with high reliability and versatility, and has certain application reference value.