Aiming at the problem of overvoltage and economical operation of distribution network with high photovoltaic (PV) penetration, an optimization method based on active and reactive power coordination is proposed. It analyzes the limitation of active power output under the voltage constraints, studies the voltage regulation mechanism, and develops an index named pure active power output. Considering the voltage constraints of special nodes, and taking the maximum pure active power output as the objective function, the integrated optimization model of active power output and losses is established. The numerical simulation results demonstrate the voltage control capability and superior economy, and the economy presents the characteristics of ascended firstly and then descended with the increase of active power output. The proposed optimization model running at the minimum losses mode under the maximum power point in common scenario, and adjust a smll amount of active power output to meet the voltage constraints in extreme scenario.