The integrated energy system can improve the flexibility of system operation and the consumption of renewable energy such as large-scale wind-PV. Aiming at the schedule ability of electric and thermal loads, this paper proposes a comprehensive electric and thermal demand response model considering the participation of dispatchers. Firstly, the group aggregation characteristics of the time-shift electrical load are modeled, and the minimum deviation of the dispatch signal from the load group aggregation characteristics model is used as the objective function. Based on the ambiguity of human body perception to temperature, a heat load scheduling model is constructed. Considering the comprehensive demand response of the expected signal of dispatchers, the results of calculation examples show that it improves the consumption of new energy and reduces the operating cost of the system, which alleviates the pressure of frequent adjustment of the output of each unit and offsets the change of the output of new energy.