In order to improve the flexibility and reliability of power line carrier (PLC) communication networking in medium voltage distribution network, based on the actual topology of the medium voltage distribution network and the channel environment, a method of PLC networking based on genetic algorithms is proposed. This method comprehensively considers factors such as the actual distance between nodes, the link loss between nodes, the connection node loss, the node"s own value, and the link value. The genetic algorithm is used to calculate the maximum value function of the network and determine the optimal link set of the network. Based on the optimal link set, the node degree of each communication node is calculated, and the higher node degree value is used as the relay node of the network, and then the PLC network of the distribution network is optimized. Compared with the ant colony routing algorithm, the algorithm considers the actual topology and channel characteristics of the distribution network, the relay node and link allocation are more reasonable, which makes the PLC network have higher network value and network transmission efficiency.