Traditional energy systems are independent of each other and lack of linkage, which easily leads to energy waste, and it is difficult to optimize the energy structure. Regional integrated energy system has the advantages of multi-energy complementation and efficient utilization, and is an important improvement technology to improve energy utilization efficiency and environmental protection. In order to take advantage of the energy contained in garbage and the energy consumption at the load end of electric vehicles, a regional comprehensive energy system model considering garbage incineration and electric vehicle load is established in this paper. Firstly, the energy circulation relationship of multiple energy sources in the system is analyzed, and then various energy conversion equipments and electric vehicles in the system are analyzed. Waste energy treatment is introduced to convert heat energy into electric energy, and electric vehicles are used to consume electric energy, so as to obtain a model for maximizing the energy efficiency of the regional integrated energy system. Finally, an example is analyzed by python, and the results show that the regional integrated energy system involving waste treatment and electric vehicles can not only improve the energy utilization efficiency, but also bring better economic benefits.