Aiming at the problem of poor economic efficiency caused by the inconsistency of the dispatch results with the output of the micro-grid under the influence of the interrupted load, an autonomous optimal economic dispatch method of the active power distribution system with multiple micro-grid access is proposed. Based on the power characteristics of the multi-microgrid, the operating cost and environmental cost of the active power distribution system are calculated. Aiming at maximizing the operating cost and environmental cost and economic benefits, we establish an objective function for autonomous optimization of economic dispatch, design the constraint conditions of the objective function from two aspects of the environmental cost and operating cost, carry out the branch power flow constraint, and limit the output power of the micro-grid, etc., so that the output power change of the distribution system is consistent with the change trend of the battery output, and the objective function is solved under the constraint conditions to obtain the objective function solution set, solve the closeness of each solution in the set to the ideal weight, filter out the optimal solution, and realize the autonomous optimal economic dispatch of the active power distribution system. The experimental results show that the designed scheduling method has low operating cost, high optimization level, stable micro-grid output power and consistent with battery output when the load is interrupted. The economic efficiency of the proposed method is improved.