Due to the disadvantages of low efficiency and high cost, the wired communication of smart energy meters is gradually replaced by wireless communication methods such as Bluetooth, WiFi, Zigbee and GSM. TheLoRa technology can solve the problems that traditional wireless communication cannot take into account low power consumption and long-distance communication at the same time. At present, there are extensive studies on LoRa-based meter reading systems and technologies, however, there are few studies on the optimization of the power consumption and anti-interference performance of the smart meter. In view of this, this paper focuses on the research of the low power consumption and high anti-interference ability of the LoRa meter, we design the system and optimize the modules to achieve long-distance communication with low power consumption, the combination of software and hardware can improve the anti-interference ability. This paper realized the coexistence of long-distance transmission and low power consumption of meter, which can simplify the design requirements and the cost investment, which is helpful to promote the construction of smart grid.