According to the output signal of the IEPE sensor data acquisition system sensor has large dynamic range and high amplitude. It is not suitable for direct collection. In order to improve the accuracy of data acquisition and reduce power dissipation, a IEPE sensor data acquisition system is designed. The design adopts a front-end signal conditioning circuit with low power and program-controlled function , a high precision analog digital conversion circuit and a micro-power supply circuit, which greatly improve the precision of the data acquisition system and reduce the power loss of the circuit. The whole data acquisition system is easy to operate, high in flexibility and low in cost. It can be widely applied in related engineering fields through experimental verification and analysis.